References on Air-Liquid Interface Exposure of Cells for Toxicology

Aoshiba, K., Yasui, S., and Nagai, A. (2000) Apoptosis of alveolar macrophages by cigarette smoke. Chest 117: 320S

Aufderheide, M., Knebel, J. W., and Ritter, D. (2003). An improved in vitro model for testing the pulmonary toxicity of complex mixtures such as cigarette smoke. Exp.Toxicol.Pathol. 55, 51-57.

Aufderheide, M., Knebel, J. W., and Ritter, D. (2003) Novel approaches for studying pulmonary toxicity in vitro. Toxicol. Lett. 140-141: 205-211.

Aufderheide, M., Knebel, J. W., and Ritter, D. (2002) A method for the in vitro exposures of human cells to environimental and complex gaseous mixtures: Application to various types of atmopshere. ATLA 30: 433-441.

Aufderheide, M. and Mohr, U. (1999) CULTEX--a new system and technique for the cultivation and exposure of cells at the air/liquid interface. Exp. Toxicol. Pathol. 51: 489-490.

Aufderheide, M., Ritter, D., Knebel, J. W., and Scherer, G. (2001) A method for in vitro analysis of the biological activity of complex mixtures such as sidestream cigarette smoke. Exp. Toxicol. Pathol. 53: 141-152.

Benson, J. M., Zamora, P. O., Dahl, A. R., and Hanson, R. L. (1983) A simple dynamic flow-through exposure system for assessment of biological activity of complex organic mixtures to mammalian cells in vitro. Am Ind. Hyg. Assoc. J 44: 211-215.

Bion, A., Fal, M., Gouriou, F., Le Prieur, E., Dionnet, F., and Morin, J. P. (2002). Biphasic culture of rat lung slices for pharmacotoxicological evaluation of complex atmospheres. Cell Biol.Toxicol. 18, 301-314.

Brown, G. M., Drost, E., Donaldson, K., MacGregor, I., and MacNee, W. (1991) Reduction of the proteolytic activity of neutrophils by exposure to cigarette smoke in vitro. Exp. Lung Res. 17: 923-937.

Cheng, M. D., Malone, B., and Storey, J. M. E. (2003) Monitoring cellular responses of engine emitted particles by using a direct air-cell interface deposition technique. Chemosphere

Cohn, L. A. and Adler, K. B. (1991) In vitro studies of mechanisms of lung injury in the rodent. Toxicol. Pathol. 19: 419-427.

Hunt, L. A. (1986) Sidestream cigarette smoke-exposure of mouse cells induces cell stress/heat shock-like proteins. Toxicology 39: 259-273.

Knebel, J. W., Ritter, D., and Aufderheide, M. (2002) Exposure of human lung cells to native diesel motor exhaust--- development of an optimized in vitro test strategy. Toxicol. In Vitro 16: 185-192.

Knebel, J. W., Ritter, D., and Aufderheide, M. (1998) Development of an in vitro system for studying effects of native and photochemically transformed gaseous compounds using an air/liquid culture technique. Toxicol. Lett. 96-97: 1-11.

Le Prieur, E., Vaz, E., Bion, A., Dionnet, F., and Morin, J. P. (2000). Toxicity of diesel engine exhausts in an in vitro model of lung slices in biphasic organotypic culture: induction of a proinflammatory and apoptotic response. Arch.Toxicol. 74, 460-466.

Massey, E., Aufderheide, M., Koch, W., Lodding, H., Pohlmann, G., Windt, H., Jarck, P., and Knebel, J. W. (1998) Micronucleus induction in V79 cells after direct exposure to whole cigarette smoke. Mutagenesis 13: 145-149.

Morin, J. P., Fouquet, F., Monteil, C., Le Prieur, E., Vaz, E., and Dionnet, F. (1999). Development of a new in vitro system for continuous in vitro exposure of lung tissue to complex atmospheres: application to diesel exhaust toxicology. Cell Biol.Toxicol. 15, 143-152.

Morin, J. P., Rumigny, J. F., Bion, A., and Dionnet, F. (2002). Isoflavones protect against diesel engine exhaust injury in organotypic culture of lung tissue. Environ.Toxicol.Pharmacol. 12, 213-220.

Ritter, D., Knebel, J. W., and Aufderheide, M. (2003). Exposure of human lung cells to inhalable substances: a novel test strategy involving clean air exposure periods using whole diluted cigarette mainstream smoke. Inhal.Toxicol. 15, 67-84.

Ritter, D., Knebel, J. W., and Aufderheide, M. (2001) In vitro exposure of isolated cells to native gaseous compounds - Development and validation of an optimized system for human lung cells. Exp. Toxicol. Pathol. 53: 386

Ritter, D., Knebel, J. W., Aufderheide, M., and Mohr, U. (1999) Development of a Cell Culture Model System for Routine Testing of Substances Inducing Oxidative Stress. Toxicology in Vitro 13: 745-751.

Seagrave, JC, McDonald, J. A., and Mauderly, J. L. (2002) Air-liquid interface culture for evaluation of cellular effects of combustion emissions. The Toxicologist 66: 99-(abstract# 485).

Shimizu, T., Shimizu, S., Hattori, R., Gabazza, E. C., and Majima, Y. (2003) In vivo and in vitro effects of macrolide antibiotics on mucus secretion in airway epithelial cells. Am. J. Respir. Crit Care Med. 168: 581-587.

Spannhake, E. W., Reddy, S. P., Jacoby, D. B., Yu, X. Y., Saatian, B., and Tian, J. (2002) Synergism between Rhinovirus Infection and Oxidant Pollutant Exposure Enhances Airway Epithelial Cell Cytokine Production. Environ. Health Perspect. 110: 665-670.

Sun, W., Wu, R., and Last, J. A. (1995) Effects of exposure to environmental tobacco smoke on a human tracheobronchial epithelial cell line. Toxicology 100: 163-174.

Tippe, A., Heinzmann, U., and Roth, C. (2002) Deposition of fine and ultrafine aerosol particles during exposure at the air/cell interface. J. Aerosol Sci. 33: 207-218.

Wolz, L., Krause, G., Scherer, G., Aufderheide, M., and Mohr, U. (2002). In vitro genotoxicity assay of sidestream smoke using a human bronchial epithelial cell line. Food Chem.Toxicol. 40, 845-850.

Zamora, P. O., Benson, J. M., Marshall, T. C., Mokler, B. V., Li, A. P., Dahl, A. R., Brooks, A. L., and McClellan, R. O. (1983) Cytotoxicity and mutagenicity of vapor-phase pollutants in rat lung epithelial cells and Chinese hamster ovary cells grown on collagen gels. J Toxicol. Environ. Health 12: 27-38.